Search results for " TOAST"

Plasma levels of inflammatory and thrombotic/fibrinolytic markers in acute ischemic strokes: Relationship with TOAST subtype, outcome and infarct site

2009

BACKGROUND: The aim of our study was to evaluate in patients with acute ischemic stroke the relationship between immuno-inflammatory variables, clinical outcome and infarct site. MATERIALS AND METHODS: We evaluated plasma levels of IL-1beta, TNF-alpha, IL-6 and IL-10, E-selectin, P-selectin, sICAM-1 ,sVCAM-1 vWF, TPA and PAI-1. RESULTS: Patients with cardioembolic subtype showed significantly higher median plasma levels of TNF-alpha, IL-6, IL-1beta whereas the lacunar subtype showed significantly lower median plasma levels of TNF-alpha, IL-6 and IL-1beta. CONCLUSIONS: A significant association was noted between the severity of neurological deficit at admission, the diagnostic subtype and so…

Risk Factors profile and clinical outcome of ischemic stroke patients admitted in a department of Internal Medicine and classified by TOAST classific…

2006

Endothelial function and arterial stiffness indexes in subjects with acute ischemic stroke: Relationship with TOAST subtype.

2017

Abstract Background and aims Only one study has examined endothelial function in subjects with acute ischemic stroke and no study has yet assessed arterial stiffness and reactive hyperemia peripheral arterial tonometry (RH-PAT) in ischemic stroke and its clinical subtypes. Our study aimed to evaluate arterial stiffness and endothelial dysfunction indexes in patients with acute ischemic stroke and the relationship between endothelial dysfunction indexes and arterial stiffness markers and stroke subtypes according to Trial of Org 10172 in Acute Stroke Treatment (TOAST) Classification. Methods We enrolled 98 patients with a diagnosis of acute ischemic stroke and 105 hospitalized patients witho…

A precise stroke classification for evaluation of ischemic stroke subtypes and their relation with diabetes: is TOAST the best?

2010

To The Editor: Regarding the study by Turin et al1 performed to estimate the secular time trends in incidence using a population-based stroke registry in Japan, we discuss some issues of potential interest. First, have the authors classified stroke subtypes according TOAST classification or Oxfordshire classification? No mention has been made in the text concerning the classification methodology of ischemic stroke. It is conceivable that applying the TOAST classification2 of ischemic stroke (a classification with clinical, pathophysiological, anatomic, and instrumental basis that is easily applicable and widely validated) could provide a more precise selection of patients with lacunar strok…

Il vino nell'opera tra convito ed ebbrezza

2022

Opera e vino sono senz'altro un connubio felice: a chiunque frequenti anche solo sporadicamente il teatro d'opera verrà in mente il famoso "Libiamo" del I atto della Traviata, nel quale si celebra il vino che abbellisce la notte e rende più caldi i baci degli amanti. Nell'opera italiana dell'Ottocento il brindisi (lieto o funesto) è un momento topico, con specifici connotati musicali e drammaturgici; la sua dimensione corale è assente nell'opera barocca, dove invece il vino serve a stigmatizzare i vizi umani. Dopo aver passato in rassegna alcuni dei più celebri momenti in cui vino e opera si uniscono, ci si soffermerà sulla figura comica dell'ubriacone nell'opera del Seicento e se ne metter…

Cerebrovascular risk factors and clinical classification of strokes

2005

Cerebrovascular risk represents a progressive and evolving concept owing to the particular distribution of risk factors in patients with ischemic stroke and in light of the newest stroke subtype classifications that account for pathophysiological, instrumental, and clinical criteria. Age represents the strongest nonmodifiable risk factor associated with ischemic stroke, while hypertension constitutes the most important modifiable cerebrovascular risk factor, confirmed by a host of epidemiological data and by more recent intervention trials of primary (HOT, Syst-Eur, LIFE) and secondary (PROGRESS) prevention of stroke in hypertensive patients. To be sure, a curious relationship exists betwee…

Polimorfismo a singolo nucleotide dei geni pro-infiammatori /anti-infiammatori e trombotico/fibrinolitici in pazienti con ictus ischemico acuto e rel…

2011

Inflammation in Ischemic Stroke Subtypes

2011

Determining the cause of stroke does influence choices for management. categorization of subtypes of ischemic stroke has had considerable study, but definitions are hard to formulate and their application for diagnosis in an individual patient is often problematic. Cerebral ischemia initiates a complex cascade of events at genomic, molecular, and cellular levels, and inflammation is important in this cascade. In 1993 for For the Trial of Org 10172 in Acute Stroke Treatment (TOAST), Adams et al] conducted a placebo-controlled, randomized, blinded study of the low-molecular-weight heparinoid given to patients within 24 hours after stroke and developed a system for diagnosis of subtype of isch…

Frequenza periferica delle cellule CD28null e tipizzazione degli aplotipi KIR e degli alleli HLA e in soggetti con ictus ischemico acuto

Introduction: Inflammation and T cell activation have been also described as involved in pathophysiology of some complication of atherosclerosis, nevertheless no study has yet evaluated the relationship between KIR aplotypes and HLA alleles and acute cerebrovascular disease. Material and methods : Between November 2013 and February 2016, all consecutive patients with acute ischemic stroke were recruited. As healthy controls we enrolled consecutive subjects without acute ischemic stroke. KIR aplotype and HLA allele phenotyping has been performed. Results : Subjects with acute ischemic stroke in comparison to subjects without acute ischemic stroke showed a significantly a higher frequency of …